Hashimoto T*, Tsubota K*, Hatabi K, Hosoi Y: FDX1 Regulates the Phosphorylation of ATM, DNA-PKcs Akt, and EGFR and affects radioresistance under severe hypoxia in the glioblastoma cell line T98G. Int. J. Mol. Sci. 26(7), 3378, 2025. https://doi.org/10.3390/ijms26073378 *These authors contributed equally to this work

Urushihara Y, Hashimoto T, Fujishima Y, Hosoi Y: AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation. Int. J. Mol. Sci. 24(16), 12828, 2023.

Hashimoto T, Urushihara Y, Murata Y, Fujishima Y, Hosoi Y: AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines. Biochemical and Biophysical Research Communications 590:82-88, 2022.

Shiga S, Murata Y, Hashimoto T, Urushihara Y, Fujishima Y, Kudo K, Sonohara Y, Kurusu M, Takeda K, Jingu K, Hosoi Y: DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1. Biochemical and Biophysical Research Communications 521:668-673, 2020.

Hashimoto T, Murata Y, Urushihara Y, Shiga S, Takeda K, Hosoi Y: Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways. Biochemical and Biophysical Research Communications 505:13-19, 2018.

Murata Y, Hashimoto T, Urushihara Y, Shiga S, Takeda K, Jingu K, Hosoi Y: Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217. Biochemical and Biophysical Research Communications 495:2566-2572, 2018．

Morita A, Takahashi I, Sasatani M, Aoki S, Wang B, Ariyasu S, Tanaka K, Yamaguchi T, Sawa A, Nishi Y, Teraoka T, Ujita S, Kawate Y, Yanagawa C, Tanimoto K, Enomoto A, Nenoi M, Kamiya K, Nagata Y, Hosoi Y, Inaba T: A chemical modulator of p53 transactivation that acts as a radioprotective agonist. Mol Cancer Ther. 17:432-442, 2018.

Fukuda K, Uehara Y, Nakata E3, Inoue M, Shimazu K, Yoshida T, Kanda H, Nanjo H5, Hosoi Y, Yamakoshi H, Iwabuchi Y, Shibata H. A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa. International Journal of Radiation Biology 92: 388-94, 2016.

Uehara Y, Murata Y, Shiga S, Hosoi Y: NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells. Biochemical and Biophysical Research Communications 479: 847-852, 2016.

Murata Y, Uehara Y, Hosoi Y: Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6. Biochemical and Biophysical Research Communications 468: 684-490, 2015.

Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H: Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo: a novel candidate for gastric cancer treatment. Gastric Cancer 18: 774-783 2015.

Morita A, Murakami T, Morinaga T, Tanimoto K, Hosoi Y: Requirement of mitochondria for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line HepG2 cells. Biochemical and Biophysical Research Communications 443: 1286-90, 2014.

Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, Nenoi M, Ikekita M, Aoki S, Hosoi Y: Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis. Oncotarget 4: 2439-2450, 2013.

Enomoto A, Fukasawa T, Takamatsub N, Itob M, Moritac A, Hosoi Y, Miyagawa K: The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition. European Journal of Cancer 49: 3547-3558, 2013.

Wang B, Tanaka K, Morita A, Ninomiya Y, Maruyama K, Fujita K, Hosoi Y, Nenoi M: Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice. J. Radiat. Res. 54: 620-629, 2013.

Putra AC, Tanimoto K, Syahruddin E *1, Andarini S *1, Hosoi Y, Hiyama K *2 (*1Dept Pulmonol Resp Med, Facul Med Univ Indonesia, *2Fukuhara Clinic). A Step forward into respiratory genetics: Overview contribution of genetics in respiratory diseases. Asian Biomedicine 5: 639-651, 2012.

Tanigawa K, Hosoi Y, Hirohashi N, Iwasaki Y, Kamiya K: Loss of life after evacuation: lessons learned from the Fukushima accident. Lnacet 379: 889-891, 2012.

Tanigawa K, Hosoi Y, Hirohashi N, Iwasaki Y, Kamiya K: Evacuation from the restricted zone of the damaged Fukushima nuclear power plant; facing with the reality. Resuscitation 82:1248, 2011.